Implantation of a Vascular Access Button for Chronic Blood Sampling and Drug Administration in the Rabbit

Rabbits are commonly used for pharmacokinetic (PK) and toxicokinetic (TK) studies in the research setting, requiring repetitive venipuncture, which can be challenging this species. The auricular vessels venipuncture rabbits. access of these delicate lead to trauma such as hematomas causing become more study progresses. In turn, leads missed time points or insufficient blood samples. Surgical models chronic vascular rabbits common throughout industry. Common include exteriorized catheters implanted ports. However, implants come with their own complications restrictions when Therefore, authors evaluated use a button (VAB), an implant small rodents, refinement current Seventeen were either single dual channel VABs. femoral artery and/or vein then tunneled subcutaneously on dorsal thoracic area. Overall, results outstanding, established model was created. average patency rate 316 days several still patent after 2 years. feel implantation routine PK is excellent refinement. tolerate buttons extremely well minimal issues. equal better than ports tethering system, provides hands-off method collection intravenous administration during studies.